Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines

Beyond Monoamines-Novel Targets for Treatment-Resistant Depression: A Comprehensive Review

Major depressive disorder (MDD) is a leading cause of disability worldwide. Current first line therapies target modulation of the monoamine system. A large variety of agents are currently available that effectively alter monoamine levels; however, approximately one third of MDD patients remain treatment refractory after adequate trials of multiple monoamine based therapies. Therefore, patients ...

Beyond PCR: Biotechnology as an Emerging Culture

the 1993 Nobel Prize for chemistry, Cetus' scientists contribution, which ultimately ended up in a drawer of Making PCR. A Story of Biotechnology. history, proved significant enough to justify an expola-rion of this issue. Hence, more than an account of the invention of PCR, Rabinow's working approach should be viewed as " an pp. $22.50 experiment in posing the problem of who has the author-ity...

Emerging Approaches to the Conceptualization and Treatment of Personality Disorder

Personality disorders are both prevalent and debilitating, but controversies abound concerning the definition, assessment and treatment of these conditions. This review examines major approaches to conceptualizing the personality disorders, as recently emerging in DSM–5, Section III, and the research domain criteria initiative of the National Institute of Mental Health. Three prominent models f...

Anhedonia in obsessive-compulsive disorder: beyond comorbid depression.

Obsessive-compulsive disorder (OCD) has been linked to reward dysfunctions, highlighting a possible role of anhedonia in OCD. Surprisingly, anhedonia in OCD has never been evaluated. Moreover, although nicotine typically has anti-anhedonic effects, anecdotal reports suggest low prevalence rates of smoking in OCD. To address these two phenomena, 113 individuals with OCD completed a battery of qu...

Neuroendocrine disruption: the emerging concept.